::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

AN EXPERIMENTAL RESEARCH TO DESIGN AND IDENTIFY THE EFFECTS OF LOW-DOSE UNITREXATE IN SECONDARY SPINAL CORD INJURIES

AUTHORS:

Dr. Maryam Suryya Zafar, Dr. Rauha Ahmad, Dr. Safina Babar

ABSTRACT:

Introduction: Various inflammatory and biochemical reactions may develop because of the SSCI (Secondary Spinal Cord Injury) effects which also known as secondary cord damage and it also creates oedema in the course of an acute stage. Objective: Keeping in view the facts, the aim of this research was to design and identify the therapeutic effects of low-dose unitrexate for neuropathological disorders. Material and methods: The design of this research was experimental in nature which was carried out at Mayo Hospital, Lahore (October 2017 to July 2018). We considered all the ethical protocols of the hospital in this research. The research sample consisted of one hundred patients who were suffering due to any of the neurological disorder and also used such drugs. The research was carried out in fragments by dividing the population into different groups. Results: The varying mean MPO level values were significant according to T-Test and ANOVA. Treated group and control group were significantly different. Outcomes reflect that combined therapy of MO and MTX present closer values to the control group; whereas, a separate effect reflects different values than the control group. Conclusion: We conclude that low-dose unitrexate is more effective than methylprednisolone to treat patients of neurological disorders. Keywords: Low-dose, Neurological, Injury, Disorder, Myeloperoxidase (MPO), MP, MTX, SCI (Spinal Cord Injury) and Unitrexate.