*Md Sohail, Mohd Yunus Siddiqui, Mohammad Mohsin, Mursaleen Naseer
Background: Siman-e-Mufrat (Obesity) is one of the most common problems worldwide; it is directly related with the changes of life style pattern of human being in this era. Therefore, there is a paradigm shift of killer disease from infectious to non-infectious diseases having almost equal mortality and morbidity. Siman-e-Mufrat (obesity) is a Balghami (Phlegmatic) disease and hence Khilt-e-Balgham predominates is a predisposing factor in causation of obesity. It causes sluggish of the metabolic function of the body and loss of movements of Aaza (organs) due to excessive accumulated Balgham (fat) and cold temperament, hence the person becomes lazy and dull. Deposition of Balgham (Atherosclerosis) obstructs Nufuz of Rooh (passage of oxygen) in the organs which finally cause death of the obese persons.W.H.O. projects that by 2015, approximately, 2.5 billion adults will be overweight and more than 700 million will be obese. The National Family Health Survey (N.F.H.S) shows that 12.1% men and 14.8% women in India are either overweight or obese. The obesity is not a single morbid condition but it invites several others to make a derangement at the level of vascular changes, visceral changes including derangement in carbohydrate, protein, fat even of mineral and water. Obesity is considered as an iceberg of many metabolic disorders including metabolic syndrome, as a result, Non-alcoholic Fatty Liver Disease (NAFLD), Diabetes Mellitus, Hypertension, CAD may emerge as a co-morbid factor. Objectives: The aim of this review articles is to describe the comprehensive concept of obesity and its co- morbidities in Unani medicine with correlation of modern concept and its prevention and management. Keywords: Siman-e-Mufrat (Obesity), Co morbidities and Unani Medicine.