::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

A REVIEW ON SOLID DISPERSION CONTAINING PHOSPHOLIPID

AUTHORS:

Osama R. Ahmed, Vishal C. Gurumukhi*, Shailesh S. Chalikwar

ABSTRACT:

The oral solubility of poorly aqueous soluble drugs endures the major challenging feature in pharmaceutical formulation. There are more than 60-70 % of the drugs suffers low aqueous solubility, which can be dramatically increased by solid dispersion. One or more active pharmaceutical ingredient is dispersed in a solid carrier to improve their dissolution and bioavailability is called solid dispersion. Phospholipid based solid dispersion is a novel formulation which is used to enhance solubility and drug release of poor aqueous soluble drugs. Phospholipids are derived from different sources such as natural and synthetic, and have the magnificent biocompatibility and particular amphiphilicity. Due to their special characteristic they are used in drug delivery system to intensify solubility and dissolution. Phospholipids have the ability to enhance the penetration across the cell membrane to deliver active drug substance which results to increase bioavailability. The present article summarized the solid dispersion types, methods, phospholipid types and their application in drug delivery system Keywords:Solid Dispersion, Bioavailability, Phospholipid, Application