Dr Maria Khalid, Dr Hassan Arslan, Dr. Ahmad Mustafa
Objective: The point of this investigation was to survey the recurrence and kinds of thyroid dysfunction that creates amid IFN-α treatment in patients of Chronic Hepatitis C. Design of Study: Case control study Place and Duration of Study: Mayo Hospital Lahore from February, 2017 to January 2018. Methods: The investigation was done on an aggregate of 50 patients of constant hepatitis C on recombinant IFN-α treatment. What's more 50 patients with perpetual hepatitis C, not on any antiviral treatment, were incorporated as controls. After educated assent, clinical history was gotten, physical examination was done and discoveries recorded on a pre-structured Performa. Blood testing was accomplished for thyroid profile toward the start of interferon treatment, at 12 weeks lastly at 24 weeks. Results: Thyroid dysfunction (TD) was seen in 14% (n=7) of the patients on antiviral treatment for CHC (n=50).Amongst these seven patients with TD, hypothyroidism was seen in 5 and hyperthyroidism in 2 patients. Conversely the recurrence of thyroid dysfunction saw in charge group (n=50) was 2%. Conclusion: The recurrence of thyroid dysfunction in patients of constant hepatitis C treated with interferon approaches 14%, with hypothyroidism being the more normally watched example. Keywords: Interferon therapy, Hepatitis C, Thyroid dysfunction.