::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

A CROSS-SECTIONAL STUDY ON ANTITHROMBIN III (AT) AS SIGN OF THICKENING OF CONNECTIVE TISSUE IN CHRONIC HEPATITIS C

AUTHORS:

Dr. Umme Habiba, Dr. Shamia Zeeshan, Dr. Muzammal Hussain

ABSTRACT:

Objective: We aimed in this study to develop the part of Antithrombin III like a non-invasive sign of the thickening and scarring of connective tissue in endurable condition in which the liver does not function properly due to long-term damage known as hepatitis C. Study design: Cross-sectional descriptive study. Place and duration: This analysis was conducted in the Department of Hematology of Federal Post Graduate Medical Institute, Shaikh Zayed Hospital, Lahore with duration of 1 year from March 2016 to March 2017. Methodology: This analysis consists of 50 patients of endurable hepatitis C. According to the histological phases of thickening of connective tissue these patients were more on separated in two groups. Group A and group B consists of phases of fibrosis 0 to 3 and 4 to 7 respectively. Number of 25 chronic hepatitis cases was included in both groups. Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), platelet and Antithrombin (AT) were processed to all cases. Results: In group A and group B the Average ± SD of cases was 96.48 ± 12.13 % and 58.92 ± 22.03 respectively where the value of P was less than 0.001.Group A and group B consists of phases of fibrosis 0 to 3 and 4 to 7 respectively. Number of 25 endurable hepatitis cases was included in both groups. Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), platelet and Antithrombin (AT) were processed to all cases. Conclusion: These outcomes presented the AT intensity which was decreased in progressive phase of fibrosis during the matching to first fibrosis phase. Confines of analysis is number of 50 patients which were sorted in this analysis which is insufficient figure to develop the antithrombin III as non-invasive signs of hepatitis C cases in people of Pakistan. The samplings were gotten and kept at temperature of 70.0 degree centigrade before analysis, the outcomes of analysis might be a little variative of the evaluation of coagulation influences of fresh samplings. Key words: Aspartate aminotransferase (AST), alanine aminotransferase (ALT), antithrombin-III (AT), fibrosis, chronical hepatitis.