::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

PREPARATION AND EVALUATION OF TAPENTADOL INSITU GEL

AUTHORS:

Dr. T. Mangilal, S.Likitha, Shaistha Tabassum, Syeda Sana Fatima, S.Nikitha

ABSTRACT:

The aim of the present study is to prepare and evaluate Tapentadol insitu gel. In the present study, an attempt was made to prepare topical analgesics gels by hydrogel/ Dispersion method by using polymer Carbopol 940 as a key ingredient which gives pH-induced sol to gel conversion of the formulations. Different formulations were prepared by varying the ratios of carbopol 940 and different grades of Hydroxyl Propyl Methyl Cellulose (HPMC K100, HPMC K4M). These formulations were evaluated for parameters like pH, drug content, viscosity, gel strength, in vitro drug release and drug excipient compatibility. In this study, the release profile depends on the concentration of carbopol 940 and grade HPMC. The gel was stable during stability studies according to ICH guidelines 30±20 C / 65±5% RH and 40± 20C / 75±5% RH for two months. It shown emollient, analgesic action on application to the skin, diffuses directly in to the systemic circulation and shows immediate action. This formulation does not show any redness, edema, inflammation and irritation on the site of application. Hence it was concluded that the gels without side effects having analgesic property can be used as provision of barrier to protect the skin. So the formulation is safe to use. Key Words: Tapentadol, Carbopol, HPMC K100, HPMC K4M,Topical analgesics gel.