Dr Kamran Khursheed, Dr Arslan Asad, Dr Hassan Iqbal
Introduction: Hypertension (HTN) is a chronic medical condition that is rarely accompanied by any symptoms. It is usually identified through screening or when the patient is seeking for an unrelated problem. Aims and objectives: The main objective of the study is to analyze the level of antioxidants in the prognosis of hypertension. Material and methods: This cross-sectional study was conducted in Basic Health Unit Punjkot Muzaffarabad during March 2018 to November 2018. The data was collected from 100 patients through non-probability random sampling technique. Blood pressure was measured with a mercury sphygmomanometer, with the patient in the sitting position after 5 minutes of rest in a quiet environment, following the recommendations of the British Hypertension Society. Systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean blood pressure (MBP) were averaged by using 3 readings measured at 5-minute intervals. Results: There was no significant relationship among age, weight, calorie, and nutrients intake in control and supplement groups. the blood levels of SOD, GPX and serum levels of TAC significantly increased, whereas the serum level of TNF-α, MMP2, MMP9, MDA significantly decreased in the supplement group compared to the control group (p<0.05). There were no significant differences between the two groups in the serum levels of other biochemical factors such as hs-CRP, IL6, and TNF-α after intense physical activity (p>0.05). Conclusion: It is concluded that the role of oxidative stress in the pathogenicity of hypertension is still not well understood. The mechanisms producing the oxidative stress status, the contribution to the dysregulation of the factors and/or mechanisms controlling normal vascular tone.