::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

A RESEARCH STUDY TO DECIDE THE IMPACTS OF PSYLLIUM HUSK ON LIPID PROFILE OF ESSENTIAL HYPERLIPIDEMIC PATIENTS

AUTHORS:

Dr. Fakiha Afzal Sani, Dr. Maham Naeem, Dr. Rohina Khizer Mufti

ABSTRACT:

Background: Psyllium husk has been utilized for treating gastrointestinal bombshells like looseness of the bowels, stoppage and peevish gut infection before. Ongoing therapeutic specialists have demonstrated exceptional impacts of psyllium husk on all parameters of lipid profile, aside from triglycerides and extremely low thickness lipoproteins. Objective: This investigation was led to decide the impacts of psyllium husk on lipid profile of essential hyperlipidemic patients. Patients and Methods: It was a solitary visually impaired fake treatment controlled exploratory study,conducted in Jinnah Hospital Karachi, from January 2009 to June 2009. Forty hyperlipidemic patients were incorporated into this investigation. Twenty patients were on fake treatment as control gathering, and twenty were on psyllium husk, ten grams every day in three separated portions, for three months. Patients with hypothyroidism, liquor abuse, renal and hepatic illness were prohibited from the examination. Serum complete cholesterol and triglycerides were assessed by the enzymatic calorimetric strategy. Serum High Density Lipoprotein (HDL) was dictated by direct technique, at the very beginning and on a day ago of the treatment. Low Density Lipoprotein, (LDL) was determined by Friedwald equation (LDL-C= TC-(TG/5 + HDL-C). Information was broke down as the mean ± standard deviation. To decide measurable importance of results, matched t-test was connected and p < 0.05 was taken as noteworthy. Results: Two patients pulled back from the examination because of individual reasons. Psyllium diminished serum all out cholesterol from 228.27±4.89 mg/dl to 199.22 ± 2.30 mg/dl, triglycerides from 169.27± 9.92 mg/dl to 164.5±8.56 mg/dl, LDL from 159.72 ± 5.70 to 129.55±2.81 mg/dl and expanded serum HDL from 34.61±1.85 to 36.77±1.96 mg/dl in three months of treatment. Aftereffects of all parameters were huge, aside from triglycerides, when paired't' test was connected for hugeness. Conclusion: It was concluded from this experimental study that psyllium husk fibers are effective in maintaining lipid profile at normal limits in hyperlipidemic patients. Key words: Psyllium hydrophilic mucilloid, Cholesterol, Lipoproteins.