::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

A STUDY ON MATERNAL SERUM TRIGLYCERIDES LEVEL IN WOMEN WITH PRE-ECLAMPSIA

AUTHORS:

Dr Muhammad Ali Zia, Dr Muhammad Tahir, Dr Urooj Iqbal

ABSTRACT:

Introduction: Preeclampsia is a potentially devastating disease of pregnancy that complicates 2%–8% of all pregnancies in the United States and can threaten the life of both the mother and her unborn child. Manifesting after 20 weeks of gestation, preeclampsia is a multi-organ disorder defined as de novo hypertension. Objectives of the study: The main objective study is to analyses the maternal serum triglycerides levels in women with pre-eclampsia. Methodology of the study: This study was conducted at Aziz Bhatti Shaheed Teaching Hospital, Gujrat during June 2018 to December 2018. The data were collected from 100 pregnant females. According to the criteria for the definition of pre-eclampsia given by the International Society for the Study of Hypertension in Pregnancy. Peripheral fasting blood specimens were collected from all control and pre-eclamptic subjects. Blood was always collected before onset of labor. Serum was separated for analysis. Triglycerides were determined after enzymatic hydrolysis with lipases. The indicator was a quinoneimine formed from hydrogen peroxide, 4-aminop- henazone and 4-cholorophenol under the under the catalytic influence of peroxidase. Results: The age of the studied pregnant females ranged between 16 and 42 years. The mean age of cases (pre-eclamptic) and controls (normal) pregnant women was 29.6 (6.1) and 29.5 (6.1) years respectively. There was no statistically significant difference in the maternal ages of both groups. Body mass index, which was only recorded at the time of blood sampling was not significantly different. Mean systolic and diastolic blood pressures were significantly higher in pre-eclamptic group than in the normal pregnant groups. Conclusion: It is concluded that the women who develop pre-eclampsia had disturbed lipid profile due to abnormal lipid metabolism. Increased triglycerides levels and delayed triglycerides clearance and high blood pressure are the reasons for the development of preeclampsia.