::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

A STUDY ON COMPARISON OF VITAMIN D LEVELS WITH BONE DENSITY AND ALKALINE PHOSPHATASE IN WOMEN

AUTHORS:

Dr Asifa Saeed, Dr Sundus Hussain, Dr Touseef Ashraf

ABSTRACT:

Introduction: Osteoporosis is a serious, worldwide, and growing health problem; WHO has estimated the 30% of all women, older than 50 years (post-menopausal) has osteoporosis. Osteoporosis is a skeletal disorder characterized by compromised bone strength predisposing a person to an increased risk of fracture. Aims and objectives: The main objective of the study is to compare the level of vitamin D levels with bone density and alkaline phosphatase in women. Material and methods: This cross-sectional study was conducted in Holy family hospital, Rawalpindi during March 2018 to November 2018. This study was conducted for the comparison of level of Vitamin D with bone density. The data was collected from 100 patients. All clinically suspected cases of osteopenia and osteoporosis with age >40 years were included in this study. The data were collected through a questionnaire in which we add all the demographic values of selected patients. Biochemical tests performed included alkaline phosphatase (ALP), serum calcium, serum phosphorus, and 25 hydroxy vitamin D(25[OH]D). Serum phosphorous, calcium and ALP were determined by spectrophotometric method, while 25(OH)D was determined by using radioimmunoassay method. Results: The data was collected from 100 individuals. There was no significant correlation (P = 0.09) between values for 25-OHD and 25-(OH)2D. Ten per cent of the women (n = 50) had serum 25-OHD levels below 12 ng mL. This subgroup also had significantly lower serum 25-(OH)2D (24.9 vs. 27.9 pg mL, P , 0.05), but they did not differ from the rest with regard to PTH and P-calcium levels. Conclusion: It is concluded that there is no significant relationship of vitamin D deficiency with decreased BMD and levels of phosphorus, serum calcium, and ALP.