Dr Anam Hassan Geelani, Dr Saira Tariq, Dr Johum Javed
Introduction: Spinal cord injury (SCI) poses a serious threat to human health and typically results in incomplete or complete loss of motor and sensory function. The prevalence of SCI is relatively high. Aims and objectives: The main objective of the study is to analyze the effects of methotrexate and methylprednisolone in spinal cord injury. Material and methods: This cross sectional study was conducted in Akhtar Saeed teaching trust hospital, Lahore during March 2018 to July 2018. Data was collected from 50 patients who were suffering from spinal injury. The study was divided into two groups, one was control group and one who was treated with MTX. Results: The data was collected from 50 patients of SCI. There were significant difference between control groups and treated groups. The data shows that the group of patients which was treated with MTX shows more close values to the control. But the separate effect shows somehow different values as compared to control. Conclusion: It is concluded that MTX therapy could improve the deficiency of MP treatment alone, enhance the neuro protective effect, inhibit the activities of inflammatory cytokines, strengthen the anti-oxidative and anti-apoptotic effects and increase the clinical therapeutic effect, which could provide new strategies for the control of SCI.