Dr Johum Javed, Dr Saira Tariq, Dr Anam Hassan Geelani
Introduction: Lung cancer (LC) is the leading cause of cancer-related deaths in the Western world. LC is divided into two main groups: non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). Objectives of the study: The main objective of the study is to analyze the level of antioxidants status in lung cancer patients receiving radiotherapy. Material and methods: This descriptive study was conducted in Holy family hospital, Rawalpindi during April 2018 to July 2018. The data was collected from 50 patients of lung cancer who visited the OPD of the hospital regularly. Patients with any other serious medical or psychiatric condition or those who had received any prior chemotherapy were excluded from the study. All patients underwent laboratory testing at baseline. Results: The data was collected from 50 patients of lung cancer. The diagnosis of LC was confirmed histologically in 27 of the patients and for the remaining nine patients the diagnosis was based on class V BAL cytology and imaging results. Twenty of the LC patients received radiotherapy, 15 of whom underwent a second bronchoscopy during RT. There were no significant differences in glutathione (p = 0.636), vitamin E (p = 0.264), TRAP (p = 0.751), TBARS (p = 0.855), Nox ( p = 0.482) or proteins (69.0 vs 72.0 g/L, p = 0.054) between the two groups at baseline. Conclusion: It is concluded that LC is associated with increased oxidative stress. The findings suggest that antioxidant responses may serve as a protective mechanism against production of ROS during RT.