- CODEN : IAJPBB
- issn 2349-7750
TITLE:
PHYTOCHEMICAL SCREENING, ANTIDIABETIC ACTIVITY STUDIES OF DIFFERENT EXTRACTS OF CLERODENDRON SERRATUM AND TELESTRIA PURPUREA IN NORMAL AND DIABETIC RATS
AUTHORS:
Chandaka Madhu, Dr. Shashi Alok, Dr. V. Raja Kumar
ABSTRACT:
The history of drugs is intimately linked with plants from the earliest times and even today plant products have extensive use in ethno medicine and traditional system of medicine. There has been a global resurgence of interest in plant based drugs due to several positive reasons. The present research work has undertaken with an objective to establish scientifically the folkloric knowledge of the East-coast districts of Andhra pradesh on anti-diabetic activity of the weeds of medicinal value of clerodendron serratum (leaves) and telestria purpurea(root). A systematic study was carried out on the selected plant extracts(alcoholic & aqueous) to find qualitative chemical characterization, acute-toxicity study, evaluation of hypo-glycemic and anti-hyperglycemic activity in rats, for its anti-hyperglycemic activity Results: The leavesextract of Clerodendron serratumand Telestria purpureashowed the presence of flavonoids, phenolic compounds, glycosides, sterols, phenolic steroids and carbohydrates. The plant extracts showed no toxicity at a dose of 2000mg/kg as per OECD guidelines. Aqueous and alcoholic extracts of Clerodendron serratumand Telestria purpurea showed dose dependent hypoglycemic and anti-hyperglycemic activity. Between the two plants, extract of Clerodendron serratum leaves extract showed good activity in normal and diabetic rats. The maximum percent blood glucose reduction of alcoholic and aqueous extracts of Clerodendron serratum and Telestria purpurea was found to be at 6th hour & 24th hour respectively. Conclusion: The selected leaves extracts of Clerodendron serratum and Telestria purpurea showed hypoglycemic and anti-hyperglycemic activity in rats. Key Words: Clerodendron serratum , Telestria purpurea, hypoglycemic and anti-hyperglycemic activity
FULL TEXT
Approved Journal
NLM ID:101711216 [Serial]
Included in EuroPub database
ICV 2015 - 61.16
Indexed In
S.J Impact Factor:7.157
cosmos Impact Factor:4.153
ICMJE Recommendations
IP Indexing Impact Factor: 2.76
Cover Page
