::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

FORMULATION AND INVITRO EVALUATION OF LAMIVUDINE NIOSOMES

AUTHORS:

T. Sravani, T. Balakrishna, A. Lakshmana Rao, S. Srinivasa Rao, M. Mallika, T. Navya Sri

ABSTRACT:

The aim of present study is an attempt to formulate and evaluate controlled release niosomal formulations by using Lamivudine drug for potentially treating HIV and AIDS related condition. Lamivudine is an antiretroviral drug for the treatment of acquired immune deficiency syndrome (AIDS) & Hepatitis. The present study involves the preparation and characterization of Lamivudine entrapped niosomes and finding the drug carrier qualities of the niosomes. The formulation L1-L6 which were prepared by varying the concentration surfactant (Tween 20 & span 20) by ether injection method. The optimized formulation of lamivudine is prepared by ether injection method was subjected to characterization studies for different evaluation parameters such as vesicle size, % entrapment efficiency, drug content, in vitro release and the stability studies was carried out at different temperature. The present study demonstrates the controlled drug release after encapsulation of Lamivudine into niosomal preparation. Key Words: Lamivudine, Niosomes, controlled release, anti-retroviral, Immunodeficiency syndrome, Hepatitis, Tween 20, Span 20.