::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

A RESEARCH STUDY TO ANALYZE THE NON-DIABETIC CHRONIC KIDNEY DISEASE PATIENT’S LIPID PROFILE WITH RESPECT TO INCREASED VLDL AND TRIGLYCERIDE CONCENTRATIONS

AUTHORS:

Dr. Aneela Tariq, Dr. Saad Asim, Dr. Tayyaba Nasir

ABSTRACT:

Objective: This research aimed to analyze the lipid profile in non-diabetic chronic kidney disease patients. Materials and Methods: This research was carried out at Allied Hospital, Faisalabad from February 2017 to July 2017 on a total of fifty non-diabetic patients having chronic kidney disease. The research sample included both male and female gender. Patients underwent a physical examination and detailed history for disease diagnosis with the support of sociological and biochemical evidence. Results: In the total sample of fifty patients twenty-seven patients showed an abnormal lipid profile and remaining twenty-three patients showed a normal lipid profile. Both patients and controls showed average value of cholesterol was respectively (202 ± 48.3) mg/dl and (186 ± 26.3) mg/dl (P-Value = 0.25). This variation in both groups was not significant. The value of Triglycerides in the CKD patients was significantly high than controls with respective (166 ± 71.8) mg/dl and (97.17 ± 17.1) mg/dl with a respective P-Value of (< 0.001). Which is higher in a significant way. The value of HDL in the patients of CKD was low than controls with respective values of (36.96 ± 6.77) and (51.0 ± 10.24) with a significant P-Value of (< 0.001) which is statistically significant. The values of LDL are more in patients than controls with respective values of (121 ± 46.51) and (116.4 ± 29.2) (P-Value 0.21) which is not significant. VLDL values were also higher in the patients than controls with respective values of (33.18 ± 14.35) and (19.4 ± 3.4) (P-Value < 0.001) which was significantly high. A significant reduced TC/HDL proportion in patients than controls with respective values of (0.19 ± 0.06) and (0.3 ± 0.08) which was high significantly (P-Value < 0.001). Conclusion: VLDL and triglyceride increased concentrations caused CVD abnormalities in the patients of CKD. A significant decrease in the HDL and total cholesterol proportions are an indicator of coronary artery diseases in all CKD patients. It is also a primary contributor to increased atherogenesis factors. In the end, the lipid profile disorders increase kidney disease progression and also abnormalities in chronic kidney disease accelerate the progression of the kidney disease and may also lead to atherosclerosis. Therefore, it is important to treat and detect the onset of hyperlipidemia in CKD patients. Keywords: CKD (Chronic Kidney Disease), VLDL (Very Low-Density Lipoprotein), LDL (Low-Density Lipoprotein, HDL (High-Density Lipoprotein) and TL (Total Cholesterol).