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TITLE:

A DESCRIPTIVE STUDY ON THE USE OF PROBIOTICS AND PREBIOTICS FOR KIDNEY STONES MANAGEMENT

AUTHORS:

Dr Tauqeer Azhar, Dr Fareeha Ghafoor, Dr Areeba Ashfaq

ABSTRACT:

Introduction: Nephrolithiasis is a complex disease influenced by genetic and environmental factors. Twin studies have revealed a 56% heritability risk for stones while other implicated factors include diet, exercise, work environment and geography. Objectives of the study: The main objective of the study is to analyze the use of probiotics for the management of kidney stone in local population of Pakistan. Methodology of the study: This descriptive study was conducted at Bahawal Victoria Hospital, Bahawalpur during March 2018 to November 2018 with the permission of ethical committee of hospital. The data was collected from 100 patients who were suffering from kidney stone. We prepare a questionnaire survey based on the knowledge and use of probiotics in local population of Pakistan. After that we ask the patients for the use of probiotics in daily life as it is considered to be the natural remedy for kidney stone. Results: The data was collected from 100 kidney stone patients. The mean age of the patients were 45±5.56 years. The oxalate tolerance by the human beings and other mammals are often regularly encouraged by the presence of oxalate-degrading microorganisms in their intestinal microbiota. One of the first oxalate degrading intestinal microbes to be characterized was Oxalobacter formigenes as it requires oxalate as a carbon and energy source. In addition ~18 other probiotics have been screened to degrade oxalate but do not require oxalate for its growth. Conclusion: It is concluded that some evidence has supported the use of prebiotics, probiotics, or symbiotic, especially for the treatment of diarrhea, their use in other disease states is controversial. The probiotics supplements are now broadly used as nutraceuticals and as health supplements.

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