::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

A DESCRIPTIVE STUDY ON THE ROLE OF LEPTIN IN ORAL WOUND HEALING IN TYPE II DIABETIC PATIENTS

AUTHORS:

Dr Muneeba Rasheed, Dr Javaria Jamil, Dr Muhammad Yasir

ABSTRACT:

Introduction: Diabetes mellitus is one of the most common chronic diseases in nearly all countries and continues to increase in numbers and significance, as economic development and urbanization lead to changing lifestyles characterized by reduced physical activity and increased obesity. Objectives of the study: The main objective of the study is to analyze the role of leptin hormone in oral wound healing in type II diabetic patients. Material and methods: This cross sectional study was conducted at Bahwal Victoria Hospital, Bahawalpur during January 2018 to October 2018. The data was collected from those patient who was suffering from type II diabetes from last 5 years. The data was collected from 100 patients through randomly sampling technique. The diabetic patient of both genders were considered for this study. For this purpose we collect the data to analyze the role of leptin hormone in wound healing process. The data were analyzed by using immunochemical assay. Results: The differences between the control and diabetic groups at the three measuring time periods were extremely highly significant (P = 0.000). Totally, the means of expression after 21 days were noticed by higher values than that after 14 days in both control and diabetic groups, while the means of expression after 7 days were the lowest one. Conclusion: It is concluded that leptin plays an important role in oral wound healing in normal patients as compared to diabetic patients. But it is not clear that why leptin is not helpful in diabetic patients. Leptin may promote wound healing in rat’s normal oral mucosa more than in diabetic.