::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

CLINICOPATHOLOGICAL AND RADIOLOGICAL FEATURES OF TRIPLE NEGATIVE BREAST CANCER: A CROSS SECTIONAL STUDY FROM A TERTIARY CARE CENTER

AUTHORS:

Dr Naila Jabeen, Dr Musarat Jehan Baloch, Dr Adina Anwar, Dr Sabir Hussain

ABSTRACT:

Objective: To assess the clinicopathological and radiological findings of triple negative breast cancer in our setting. Methodology: A cross sectional descriptive study was conducted between March 2019 to January 2020 at Dow Institute of Radiology, Dow University of Health Sciences, Ojha Campus. All patients 18 years or older who presented for a mammography and diagnosed for triple negative breast cancer were included while patients who were being treated at the time of the study, or had breast conserving surgery were excluded from the study. Data was recorded in a pro forma and was analyzed using SPSS version 24. Mean age (SD) at diagnosis, breast density, & other variables were presented as mean while the categorical data was presented as percentage. A p-value of 0.05 was considered statistically significant. Results: A mean age (SD) at diagnosis of 59.6 (6.4) years was observed. A frequency of 214 (19.1%) was reported for triple negative breast cancer. 1/3rd patients had grade II while 3/4th had grade III tumors. One-half of the patients had lobulated masses, one-third were irregular while only a minority were oval shaped. There were no calcifications observed. Patients with triple negative breast cancer were more likely to have advanced disease and younger populace (p<0.001). Conclusion: The study findings indicate that triple negative breast cancer are associated with more aggressive clinicopathological and radiological findings. Further large scale studies are needed to truly understand the role played by molecular variation in breast cancer in relation to the prognosis and treatment outcome. Keywords: Breast carcinoma; mammography; radiology; triple negative breast cancer; ultrasound.