- CODEN : IAJPBB
- issn 2349-7750
TITLE:
FORMULATION AND EVALUATION OF SUSTAINED RELEASE FLOATING MATRIX TABLET FOR HERBAL ANTI-MALARIALS
AUTHORS:
Bhati Deepak, Sable Kundan, Havelikar Ujwal, Ghuge Saurabh, Bhalekar Shriram
ABSTRACT:
Gastro-retentive system can remain in the gastric region for several hours and hence prolong. The gastric residence time of drug and improves the bioavailability. The aim of the work was to develop sustained release floating matrix tablet for hydro alcoholic extract of neem using psyllium husk as release controlling polymer drug and sodium carbonate as gas generating agent. The anti-malarial activity was due to hydro alcoholic extract of neem. The tablet was prepared by direct compression method. The formulated tablets were evaluated for different parameters like, thickness, Swelling index, friability, weight variation, hardness and in vitro drug release. It was observed that formulation containing combination of psyllium husk, and HPMC K -100 M, with NaHCo3 as gas generating agents can be promising way for formulating gastro retentive drug delivery system. Keywords: Gastroprotective floating Tablet, Antimalarials, Neem Extract, Evaluation and Formulation
FULL TEXT
Approved Journal
NLM ID:101711216 [Serial]
Included in EuroPub database
ICV 2015 - 61.16
Indexed In
S.J Impact Factor:7.157
cosmos Impact Factor:4.153
ICMJE Recommendations
IP Indexing Impact Factor: 2.76
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