- CODEN : IAJPBB
- issn 2349-7750
TITLE:
DYSLIPIDEMIA: PATHOPHYSIOLOGY, PLASMA ATHEROGENIC INDEX AND EFFECTCS OF GINGKO BILOBA IN EXPERIMENTAL RATS
AUTHORS:
Farzana Rahim Memon, Navaid Kazi, Salma Farrukh Memon, Ashfaque Rahim Memon, Salahuddin Shaik, Aftab Hussain Pathan
ABSTRACT:
Hyperlipidemia is the root cause of the common cardiovascular diseases like IHD and atherosclerosis globally related to morbidity and mortality. Hyperlipidemia is a controllable disease both through pharmacological and non-pharmacological interventions. Large variety of drugs is available but every class has its advantages and disadvantages Omega-3 fatty acids are also among the currently used drugs with promising results. Ginkgo biloba, an old Chinese herb has drawn attention in clinical research with proven efficacy in multiple disorders. This study evaluated the lipid lowering potential of Ginkgo biloba (GkB) alone as well as combined with Omega-3 fatty acids. Atherogenic index of plasma and serum CRP levels were measured in experimental rats following interventions with high fat diet. 50 Albino male Wistar rats were grouped into 5 equal groups (A, B, C, D, E), group A being the normal control, group B was positive control (High fat diet400mg/kg), group C was administered Omega -3- Fatty Acids 571mg/kg and high fat diet while group D was on G. Biloba 50mg/kg along with high fat diet and Group E:combined mixed therapy of Omega-3-FAs GkB and high fat diet were combined in group E. Experiments were carried out over one month followed by sacrifice and collection of blood samples was done. Lipid profile and CRP were measured at Isra research lab. Atherogenic index was calculated dividing triglycerides with HDL .It was observed that GkB significantly reduced plasma atherogenic index and serum CRP level when compared on ANOVA using SPSS 22nd version difference between serum triglycerides, HDL and atherogenic index was significant with p-values 0.01,0.001 and 0.0001respectively along with CRP with p-value 0.001. CONCLUSION: Ginkgo biloba reduces the atherogenic index of plasma as well as serum C-reactive protein levels KEY WORDS: Triglycerides, Gingko Biloba, HDL, Omega-3 Fatty acids, atherogenic index
FULL TEXT
Approved Journal
NLM ID:101711216 [Serial]
Included in EuroPub database
ICV 2015 - 61.16
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S.J Impact Factor:7.157
cosmos Impact Factor:4.153
ICMJE Recommendations
IP Indexing Impact Factor: 2.76
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