::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

TECHNOLOGICAL DEVELOPMENT OF OINTMENT BASED ON ETHANOLIC EXTRACT OF LIBIDIBIA FERREA FOR ANTIMICROBIAL ACTIVITY

AUTHORS:

Eulina Tereza Nery Farias, Thaís Fernandes da Silva, Suellen Emilliany Feitosa Machado, Maria Joanellys dos Santos Lima, Gláucia Manoella de Souza Lima, Karolynne Rodrigues de Melo, Victor de Albuquerque Wanderley Sales, Pedro José Rolim Neto, Maria do Carmo Alves de Lima, Rosali Maria Ferreira da Silva

ABSTRACT:

The development of new antimicrobial agents is important for public health. Libidibia ferrea (jucá or pau-ferro) is a species of Fabacea family widely used in folk medicine for its numerous therapeutic properties, which indicates the presence of compounds of pharmacological interest, including flavonoids and tannins, which are responsible for several biological activities, as well as antimicrobial activity. Thus, the objective of this work was to technologically develop an ointment based on L. ferrea and to evaluate its antimicrobial potential. The physicochemical characterization of the powder (particle size distribution, thermogravimetric analysis (TGA), loss on drying and total ash determination), the characterization of the fluid extract (determination of pH, relative density and dry residue, phytochemical prospection and determination of total flavonoid content (TFC)), and tests for antimicrobial activity of the extract and ointment based on the extract were performed. The powder was classified as moderately thick, with values of 0.3499% and 0.0635% of loss on drying and total ash determination, respectively; thermogravimetric analysis revealed three mass loss events; the fluid extract present pH value of 4.29; relative density of 0.98276 g/mL and dry residue of 3.0984%. Tannins, saponins and flavonoids were found in the phytochemical prospection. The ethanolic extract of Libidibia ferrea seeds and the ointment based on the extract showed promising antimicrobial activities against Staphylococcus aureus, followed by Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumoniae strains. In conclusion, the developed ointment presented the potential to be used as an antimicrobial agent against microorganisms responsible for major infections. Keywords: Libidibia ferrea. Herbal medicines. Seed. Semi-solid pharmaceutical forms. Antimicrobial.