::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

LEVEL OF SERUM ZINC IN PATIENTS SUFFERING FROM THALESSEMIA MAJOR AND ITS COMPARISON WITH SERUM ZINC LEVEL OF HEALTHY POPULATION

AUTHORS:

Wania Ashfaq, Zara Amjad, Aqsa Rahat

ABSTRACT:

Objective: This research work carried out to provide the comparison of level of serum zinc between the patients suffering from TM (Thalassemia Major) and normal healthy population at Allied Hospital Faisalabad. Methodology: A sum of 25 male and 36 female patients suffering from Thalassemia Major were the participants of this research work. Out of total 61 patients, treatment of 30 patients carried out by Deferoxamine and treatment of 31 patients carried out with the combination of deferoxamine and DEF (Deferiprone). We also selected 60 healthy persons with age and gender match in the group of healthy population. We obtained two milliliter blood from every participant of both groups in condition of fast. Count of complete blood and serum zinc carried out for the participants of both groups. Results: The average age of the patients and participants of normal group was 15.0 ± 5.0 years. Average level of serum zinc was 68.97 ± 21.12 μg/dl, 78.1 ± 28.5 μg/dl and 80.16 ± 26.54 μg/dl in patients of Thalassemia Major with deferoxamine, Thalassemia Major with deferiprone plus deferoxamine and participants of healthy population group correspondingly. There was no important association between all three groups. However, 50.0% Thalassemia Major patients with deferoxamine, 38.70% Thalassemia Major patients with deferoxamine plus Deferiprone and 32.80% participants of normal group were present with hypozincemia. Conclusion: Approximately 40.0% to 50.0% patients of Thalassemia Major and 1/3rd of healthy population was present with hypozincemia. This research work conclude that low serum zinc level is a serious health issue in the patients of Thalassemia Major as well as normal healthy population of the region. KEY WORDS: Serum, Zinc, Thalassemia Major, Deferoxamine, Deferiprone, Hypozincemia, Blood Count.