::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

CLINICAL PROFILES OF THE CHILDREN’S SUFFERING FROM KAWASAKI DISEASE AND ITS OUTCOMES

AUTHORS:

Dr Ammara Iqbal, Dr Amira Batool, Misbah Rahat

ABSTRACT:

Objective: To elaborate the data of demography, clinical results, laboratory findings, echocardiographic outcomes, treatment and outcome in the children suffering from Kawasaki Disease. Methodology: This is retrospective research work. This research work carried out in Jinnah Hospital, Lahore from June 2014 to January 2020. All the children who were fulfilling the criteria of Kawasaki disease in accordance with the prescription of AHA (American Heart Association) and guidelines of American Academy of Pediatrics were the participants of this research work. Results: We included 25 patients who were fulfilling the criteria of Kawasaki Disease. The average age of the patients was 43 months with a range from 4 to 150 months. There were 76% male patients. 72.0% (n: 18) patients were suffering from complete Kawasaki Disease and 28.0% (n: 7) patients were suffering from incomplete Kawasaki Disease. Fever from greater than 5 days was available in 80.0% (n: 20) patients. 32.0% (n: 8) patients were present with echocardiographic alterations, among them 25.0% (n: 2) patients had complete Kawasaki Disease and 75.0% (n: 6) patients had incomplete Kawasaki Disease. We gave intravenous immunoglobulin to every patient of the study. 60% (n: 15) patients obtained intravenous immunoglobulin in 10 days of the fever. There was no requirement of 2nd dose in any patient. We gave high dose of aspirin to all the patients at the time of diagnosis which was decreased to anti-platelet dose after fever resolution for ≥ 2 days. 72% (n: 18) patients completed whole follow up. The follow up of complete six months displayed the resolution of the echocardiographic alterations in 75.0% (n: 6) patients, 12.50% (n: 1) patient did not complete follow up and 12.50% (n: 1) patient was present with the persistent dilatation of coronary artery. Conclusion: There was prevalence of complete Kawasaki Disease in 72% patients. There was presence of abnormalities of coronary artery in 1/3rd of these patients, at younger age and it was more frequent among those patients present with incomplete Kawasaki disease but most of the patients recovered from this disease. KEYWORDS: Coronary Artery, Dilatation, Kawasaki, Immunoglobulin, Abnormalities, Echocardiographic.