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Dr. Affaq Yousaf, Dr. Muhammad Faiz Ullah, Dr Maryam Masood
Objective: It is necessary to identify risk aspects for epilepsy and febrile seizures (FS). Studies on the role of melatonin in these seizure syndromes are partial. This study determines the relationship among FS, serum melatonin levels and epilepsy in children. Place and Duration: In the Pediatric Unit II of Services Hospital Lahore for one-year duration from March 2019 to February 2020. Material and Method: A group of 111 children (37 children per group respectively) with simple FS, complex FS and epilepsy was considered as a group of cases. In addition, 37 children with non-seizure fever were the control group. Serum melatonin levels were measured and compared among all groups. Results: Serum melatonin levels in simple, epilepsy groups and complex FS were 2, 2.4 and 2 pg. The serum melatonin level in the control / ml group was 2.1 pg. In addition, no significant difference was seen when comparing case groups. Conclusion: This study shows that there is no relationship among serum melatonin levels and simple or complex epilepsy and FS. Melatonin does not play a role in seizure disorders. Keywords: epilepsy, Simple febrile seizures, Complex febrile seizures, melatonin