Dr. Zubair Maqbool, Dr. Zainab Haq, Hafiz Muhammad Umair, Azhar Hussain
Introduction: Several prophylactic measures have been suggested to avoid infection by HBV and HCV in the HD patient. Strict adherence to universal precautions along with isolation of HBV and HCV infected dialysis patients might help to control disease spread in HD units. Objectives: To determine the frequency of hepatitis B in patients of chronic kidney disease on maintenance hemodialysis and its relationship with number of hemodialysis sessions. Materials & Methods: This descriptive cross-sectional study was conducted in Lahore General Hospital, Lahore, Pakistan started from April 2019 and completed in August 2019. A total of 270CKD patients undergoing maintenance hemodialysis for at least 3 months, 18 to 80 years of age of both genders were included. Patients who received anti-viral therapy during last 6 months and with other known causes of raised liver enzymes were excluded. Blood samples were taken from the arterial line immediately after insertion of the needle (before dialysis was started). A real time PCR apparatus HBV RG PCR kit from QIAGEN (detection limit=100 copies/ml) was used for the detection of HBV DNA. HBV was diagnosed. Results: In our study, frequency of patients with various number of sessions of hemodialysis in patients of CKD on maintenance hemodialysis is found as follows; <50 in 87 (32.22%), 50-100 in 100 (37.04%), 100-200 in 69 (25.56%) and >200 in 14 (5.19%) patients. Frequency of hepatitis B was found 15 (5.56%) patients of CKD on maintenance hemodialysis. Among 87 cases with dialysis <50 times, 02 patients (3.45%) were HBV DNA detected. A total of 100 patients with dialysis 50-100 times 6 patients (6.0%) were HBV DNA detected. Out of 69 patients 100-200 times dialysed patients 05 patients (7.25%) were HBV DNA detected. Similarly, out of 17 patients >200 times dialysed patients, 1 patient (5.88%) was HBV DNA detected with p-value of 0.749. Conclusion: This study concluded that frequency of hepatitis B was found 5.56% in patients of CKD on maintenance hemodialysis with no significant difference in various number of sessions of hemodialysis. Keywords: Chronic kidney disease, Maintenance hemodialysis, Hepatitis B.