::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

FACTORS SUBSIDIZING TO ALTERATIONS IN THE CONSCIOUSNESS LEVEL OF PATIENTS WITH DIABETIC KETOACIDOSIS

AUTHORS:

Dr Maha Waheed, Dr Ali Zafar, Dr Alina Nazir

ABSTRACT:

Aim: The relationship between serum osmolality, glucose, sodium, bicarbonate, arterial pH, BUN and level of consciousness was studied in 189 patients with ketoacidosis (DK). Even if there was a statistically significant difference, there was a significant overlap of all laboratory values between the different groups. Place and Duration: In the Medicine Unit II of Nishter Hospital Multan for one-year duration from March 2019 to February 2020. Methods: To find a better predictor, we identified a new factor such as serum / arterial PH. This factor was significantly higher in sleepy and stupid patients than in drowsy and stuporous patients (p = 0.007 and p = 0.03, respectively), but it did not differ between stuporous and comatose patients (= 0.46). Again, groups can overlap. There was at least one other problem, either as a coexisting or a precipitating factor, in 18 (23.3%) of the alert, 24 (29.2%) of the drowsy, 11 (43.4%) of the stuporous and 4 (57.1 %) of the comatose group. Conclusion: It is routine to consider and exclude any of these clinical biochemical parameters as a reliable predictor of the level of consciousness in patients with DK and other altered consciousness conditions that may occur in patients with diabetes. Key words: ketoacidosis, serum osmolality, arterial pH, level of consciousness.