::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

GLOBAL ANALYSIS OF AMYLASE EXPRESSION IN CONTROL, POSITIVE AUTOANTIBODIES AND TYPE 1 DIABETES PANCREATIC TISSUES

AUTHORS:

Dr Sharjeel Ahmed, Dr Mustafa, Dr Sana Asad

ABSTRACT:

Inside the human pancreas, exocrine and endocrine cells individually control the discharge of stomach-related compounds and the creation of hormones to maintain metabolic homeostasis. While most research efforts in type 1 diabetes have focused on endocrine capacity and autoimmunity, late reviews have recognized a unique progression: the key facts (e.g., decreased weight and volume, increased leukocyte thickness) within the exocrine pancreas at present, the instruments that hide these distortions are obscure. Subsequently, we histologically evaluated amylase, insulin, glucagon, lipase and, in addition, trypsinogen in 80 organs of the donor pancreas from birth to adulthood in control subjects and those at different stages of type 1 diabetes. While amylase-positive acinar cells were visible in the pancreas of all samples examined, the tissues of people over 3 years of age contained clusters of non-amylase-positive acinar cells. Our current research was conducted at Jinnah Hospital, Lahore from August 2018 to July 2019. The majority of these AMY2 cell clusters were confined to the proximal portion of the islets of Langerhans. In addition, most of the AMY2 clusters were certain for lipase and exocrine protein trypsinogen. Curiously, the pancreas of type 1 diabetics showed a significant decrease in the recurrence of these AMY2 cell groups. These results reinforce the involvement of the islet cell linchpin in the advancement of the pancreas and highlight potential work for the exocrine pancreas in the pathogenesis of type 1 diabetes. Key words: Global Analysis, Amylase Expression, Positive Autoantibodies, Type 1 Diabetes.