::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

FREQUENCY OF ONYCHOMYCOSIS & TINEA PEDIS IN PATIENTS SUFFERING FROM TYPE-2 DIABETES AND DEVELOPMENT OF FOOT ULCER

AUTHORS:

Dr Salman Ahmed, Sumaira Liaqat, Dr Tehreem Azmat

ABSTRACT:

Objective: Decreased cellular immunity leads to the development various infection of bacteria and fungi because of the not controllable hyperglycemia in the patients suffering from diabetes. This research work aimed to evaluate the frequency of tinea pedis and onychomycosis in the patients with Type-2 diabetes and impacts on the development of other complications like foot ulcer. Methodology: The recruitment of 227 patients of diabetes carried out in this research work. Total 43 patients were present with diabetic foot ulcer. Screening of the patients carried out and record of the traits of demography was maintained. We also recorded the levels of HbA1c of the patients as well as availability of the complications. The examination of the patients carried out dermatologically and gathered specimens by scalpel from the skin between sole, toes, nails of toe and area around nails which was suspected to have infection of fungi. Results: There was high native positivity between toes in males as compared to females (P < 0.050). We found an important association between evaluation of level of HbA1c and native positivity among toes (P < 0.050). Infection because of fungi between toes, sole and nails of toe nail significantly enhanced in the diabetic patients with foot ulcer as compared to the diabetic patients without foot ulcers (P < 0.050). Moreover, native positivity in diabetic patients with foot ulcer associated with the availability of the fungal infection according to the findings of examination (P < 0.050). Conclusion: There was more fungal infections in the patients with poor glycemic control in the patients of diabetes and the infection due to fungi may be accountable for development of diabetic foot ulcer. KEY WORDS: Foot ulcer, Type-2 diabetes, accountable, onychomycosis, glycemic control, positivity, toes, HbA1c.