::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

ABOUT THE MECHANISM OF THE CONTRACEPTIVE ACTION OF SILVER-CONTAINING INTRAUTERINE DEVICES

AUTHORS:

Petrov Yu.A., Kupina A.D.

ABSTRACT:

Aim. The purpose of this study was to perform the histochemical study of the glycogen content in the endometrium of women using silver-containing intrauterine contraceptives for a different time period: from 6 months to 7 years. Materials and methods. The mucous membrane of the uterus was studied in 94 healthy women aged 22–43 years in various phases of the menstrual cycle. The control group included 20 healthy women aged 22 years to 39 years who did not use IUDs during the examination, but later using this type of contraception. Endometrial biopsy was performed at various phases of the menstrual cycle. Glycogen was detected by the Shabadash method with the control treatment of sections of saliva amylase for 5 minutes. The histological examination of the endometrium was performed (stained with hematoxylin and eosin). Histochemical reactions to glycogen were quantified by the Astaldi method as modified by A. B. Pavlova et al. Results. During the study it was found out that the revealed decrease in the amount of glycogen in the endometrial stroma in the secretory phase and the tendency to the accumulation of glycogen in the endometrium during the proliferative phase of the menstrual cycle when using silver-containing IUDs can be considered as the change in the functional state of the mucosa under the influence of the IUD. Keywords: silver-containing intrauterine contraceptive devices, glycogen, mechanism of action, endometrium.