::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

STUDY OF THE ENDOMETRIAL INNATE IMMUNE RESPONSE TO TLR9 AGONIST THERAPY.

AUTHORS:

Kosykh E.V., Korotkikh I.N., Filin A.A.

ABSTRACT:

The morphological structure of the endometrium is a very important link in the formation of a healthy pregnancy, and the innate immune response in the uterine mucosa is important for establishing the microenvironment during pregnancy. The cells of innate immunity penetrate the decidual tissue and accumulate at the attachment sites of the trophoblast. The main such cells that may be mediated are toll-like receptors. Currently, there is growing evidence that the innate immune response is activated by uteroplacental interaction, i.e. direct involvement of the endometrium as a structural component. Toll-like receptors are transmembrane proteins that can evolutionarily recognize bacteria, viruses, fungi and parasites. The study of immunity parameters with the use of TLR9 agonists (Derinat) in women with chronic endometritis associated with infertility in women of reproductive age. The drug belongs to the pharmacotherapeutic group: immunomodulatory agents, regenerant, reparant, according to published data, derinat has the properties of an agonist toll-like receptor agonist. The result of the study showed that the use of derinate improved reproductive function in women whose IVF was previously ineffective. Key words: Chronic endometritis, failed IVF attempts, TOLL-like receptors, innate immunity, TLR9 agonist.