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DETERMINATION OF HEPATOPROTECTIVE ACTIVITY OF CHRYSANTHEMUM BALSMITA AGAINST PARACETAMOL INDUCED HEPATO TOXICITY IN ALBINO WITSAR RATS

*MehnoorFarheen,*Sabura, *Asmaa, Jabeen Fatima, Khadija Ameen, Zehra Fatima

The study was performed to determine hepatoprotective activity of Chrysanthemum Balsamita herb against paracetamol induced hepatotoxicity. It was found that that the extracts of test compound posses a significant hepatoprotective activity which is evident by the prevention in the elevation of serum bio chemical parameters like SGPT, SGOT, ALP and BIT. It can also be determined by the presence of steroidal compounds, flavanoids, tannins, sugar as in certain therapies they are being used for the treatment of liver diseases by regeneration of damaged liver cells. Abbreviations: IU/L international unit per year, OECD- organization for economic cooperation and development, PCM- paracetamol, SGOT- serum glutamate oxaloacetate transaminase, SGPT- serum Glutamate Pyruvate Transaminase, P.O-orally, LD50- lethal dose for 50, SIL-Silymarin, BIT- Total bilurubin, ALP- alkaline phosphatase, extract- chrysanthemum balsamita Ethanolic extracts.

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