ResearcherID - CLICK HERE Scientific Journal Impact Factor (SJIF-2020) - CLICK HERE

EVALUATION OF THYROID FUNCTION TEST IN NEPHROTIC SYNDROME PATIENTS

Dr. Tahira Jabeen, Dr. Sadia Bashir, Dr. Shaheena Nawab

Objective: To evaluate the thyroid dysfunction in patients of nephrotic syndrome presenting at BVH Bahawalpur. Material and methods: In this cross-sectional study total 39 patients of nephrotic syndrome having age >18 years, both male or female were selected from Department of Pathology, Quaid-e-Azam Medical College Bahawalpur from October 2018 to April 2019. Thyroid dysfunction was assessed in selected patients. Results: Thirty-nine patients presented with newly diagnosed NS. The mean age of the study population was 34.89±9.14 years and was not significantly different from that of controls (n=39). When compared to the age and sex matched control group, patients with NS had significantly higher TSH and significantly lower TT4, TT3, FT3 and FT4 Conclusion: The study confirms that significant number of adult patients with NS have abnormalities in thyroid function tests. Most of these abnormalities improve with remission of NS. Anti-TPO antibodies tend to be more common in adult NS patients than control group and those with elevated anti-TPO are more likely to progress to overt hypothyroidism. Hence, all patients with NS who have elevated TSH should be evaluated for anti-TPO and those with elevated anti-TPO should be closely followed-up or replaced with LT4. Key Words: Nephrotic syndrome, Proteinuria, Hypothyroidism, Anti thioperoxides antibodies.

FULL TEXT