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EFFICACY OF TRIPLE REGIMEN THERAPY FOR H. PYLORI ERADICATION WITH AND WITHOUT AZITHROMYCIN

Dr Toufique Ahmed Odho, Dr Qurban Hussain Sheikh, Dr Sameeullah Odho, Dr Mohammad Afzal Odho

Introduction: Among the new options against H pylori brought to light recently, azithromycin has attracted substantial interest. Clinical trials with triple therapy regimens that contain azithromycin have reported eradication rates of approximately 60%-80%, depending on the regimen and azithromycin dose used. Objective: To compare the efficacy of triple therapies for H. pylori eradication with verses without Azithromycin in patients with active duodenal ulcer Setting: Department of Medicine, Jinnah Post Graduate and Medical Centre, Karachi. Study Design: Randomized controlled Trial Duration of Study: Six months started on December 14, 2013 to June 13, 2014 Subjects and Methods: All patients of either gender with age 30-60 years presented with active duodenal ulcer with H Pylori and duration of symptoms more than 3 months were enrolled. Group A was prescribed Azithromycin 1 g OD for the first 3 days (total dose 3 g), amoxicillin 1 g bid and omeprazole 20 mg bid (OAA). Group B metronidazole 500 mg bid, amoxicillin 1 g bid and omeprazole 20 mg bid (OAM). Both the therapy was given for 1 week, followed by monotherapy of Omeprazole 20 mg OD in both groups for 3 weeks. At the end of the 8th week endoscopy and urea breath test was performed.Results: Mean age of the patients was 44.06 ±8.70 years. Mean duration of symptoms of the patients was 5.91 ±1.36 months. Male preponderance was found to be higher 35 (58.30%) as compared to female 24 (40%). In patients presented in OAA triple therapy group, efficacy was found in 19 (63.3%) patients whereas, in patients presented in OAM triple therapy group, efficacy was found in 8 (26.7%) patients (p-value 0.004). Conclusion: The efficacy of triple therapies for H. pylori eradication with Azithromycin is more versus without Azithromycin in patients with active duodenal ulcer Key Words: Efficacy of Triple Therapies, H. Pylori Eradication, Azithromycin, Active Duodenal Ulcer

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