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CAPSAICIN – BENEFICIAL EFFECT OF ORIENTAL SPICE ON SKIN, HEART AND CANCER CELLS

*Shahnai Basharat, Syed Amir Gilani, Muhammad Mustafa Qamar, Ayesha Basharat, Waqas Ahmad , Qurba Kiran , Nyla Basharat

BCapsaicin is known as the primary pungent principle in Capsicum fruits. It is a compound found in chilli peppers that are massively consumed spices throughout the world. Capsaicin is a highly selective agonist for TRPV1 (transient receptor potential cation channel, subfamily V, member 1) receptor. TRPV1 is essential in reducing oxidative stress, inflammation and pain sensations. Thus, it has many pros related to health issues. The positive impact of TRPV1 and its activation via capsaicin has been studied in cardiovascular diseases, various cancers, dermatological conditions, diabetes, and obesity and many other health-related problems. With the help of previous experimental studies, capsaicin improves the heart health by reducing high blood pressure, high cholesterol levels and many other heart-related diseased complications. The TRPV1 also plays a major role in skin health as the capsaicin receptor is present in nociceptive nerve fibres and non-neural structures. It stimulates the release of a compound that is involved in communicating pain between the spinal cord nerves and other parts of the body. This review article will add growing evidence for the beneficial role of capsaicin and TRPV1 helps to lower the risk of cardiovascular diseases and conditions related to skin diseases. Key Words: Capsaicin, TRPV1 Receptor, Heart Health, Skin Health

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