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A STUDY TO DETERMINE HEPATOCELLULAR CARCINOMA PREVALENCE IN CIRRHOTIC PATIENTS

Dr Muhammad Awais, Dr Syeda Rubbab Naqvi, Dr Hidayatullah

Objective: To evaluate the hepatocellular carcinoma prevalence in patients with cirrhosis. Study design: A prospective observation study. Place and duration: In the Gastroenterology department of Mayo Hospital Lahore for two year duration from May 2017 to May 2019. Methods: 301 patients with liver cirrhosis were included. Basal abdominal ultrasound, abdominal computed tomography (CT), alpha-fetoprotein (AFP) show hepatocellular carcinoma (HCC) were not detected in selected patients and those were 194 cases and was the final sample size. Patients were prospectively followed up in selected cases for detection of HCC by ultrasonography and AFP, liver biopsy and abdominal computed tomography every 6 months. Results: The total patients were 194 with 45.1 + 13.1 years mean age; men: women 6.1: 1.0), 154 had type A child’s disease, 40 with B disease. The cause of cirrhosis in 54 (27.8%) was hepatitis C, 71 (36.6%) with hepatitis B, in 12 (6.2%) cases both hepatitis B and C and others including alcoholic, cryptogenic cirrhosis and autoimmune in 57 (29.4%) subjects. Conclusion: In our analysis, the prevalence of HCC in liver cirrhosis patients was found to be moderate, lower than Japan, but advanced than those stated in Europe. Key Words: Incidence, cirrhosis, hepatocellular carcinoma.

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