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RATE OF OCCURRENCE OF INFECTION OF HCV AND DISTRIBUTION OF ITS GENOTYPES IN NON-URBAN AREAS OF NAROWAL, PAKISTAN

Dr Zia Ul Mustafa, Dr Muhammad Ali, Muhammad Aleem Uddin

Objectives: The aim of this research work is to find out the rate of occurrence of infection because of HCV and distribution of its genotypes in the non-urban remote areas of Narowal, Pakistan. Methodology: Retroactive research on the patients visiting the for free liver tests and examined for the identifiable antibodies of HCV and patients who screened for the infection of HCV prior to the donation of the blood in Sughra Shafi Medical Complex Narowal. Elisa was in use for the testing of the antibodies of HCV. A sum of 900 patients tested reactive to antibodies of hepatitis C virus & who could economically afford to get HCV-RNA tested by the PCR, were present with their analyzed results. 190 patients were also present with their genotyped HCV. Results: Patients visiting for free liver tests were present with high chance to be reactive for the antibodies of HCV in comparison with the willing blood donors (18.0% versus 12.0%). HCV-RNA was identifiable in 700 patients out of 900 with 86.0% patients. In typable genotypes, total 100 out of 130 (73.0%) patients were present with a single genotype & seven (2.0%) patients were present with infection of genotype-1, either alone (4) or with the combination of 3A. Conclusions: One patients among 5 tested for liver tests and 12.0% of the healthy donors of blood were present as positive for antibodies of HCV. Genotype-1 is not common in our areas. Key Words: Chronic Hepatitis, Antibodies, HCV, Infection, Genotype, Donors, (Polymerase Chain Reaction).

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