ResearcherID - CLICK HERE Scientific Journal Impact Factor (SJIF-2020) - CLICK HERE

DIAGNOSTIC AND PROGNOSTIC IMPORTANCE OF CREATININE PHOSPHOKINASE IN HEAT STROKE

Kumayl Abbas Meghji, Ali Abbas Thalho, Mahum Shahab Memon, Fawad Ahmed Khilji, Ahsan Aslam, Usaid Arain

Objective: To assess the diagnostic and prognostic importance of Creatinine Phosphokinase in patients suffering from heat stroke. Methodology: 47 patients diagnosed with heat stroke in May and June 2018 were included in this study. All patients were observed for 24 hours from the time of admission. Patients were divided into three groups according to the prognosis: Group I (survived and discharged), group II (survived by remained unconscious until the study duration) and group III (Died within the study duration). Blood samples of all patients were collected at 0,6,12 and 24 hours from the time of admission to assess plasma levels of creatinine phosphokinase. Results: Out of the 47 patients, 29 (61.7%) were male and 18 (38.3%) were female. A steady rise in plasma Creatinine Phosphokinase levels was observed in patients of all three groups. Statistically significant differences between all three groups were observed through multiple comparisons by ANOVA. Post hoc analysis revealed that serum CPK levels were significantly high (p = ≤0.05) in Group III patients compared to Group II and I. However, difference in levels of serum CPK between group I and II was not significant (p = >0.05). Conclusion: Creatinine phosphokinase can be an important diagnostic and prognostic tool in patients suffering from heat stroke. Key Words: Creatinine phosphokinase, heat stroke, hyperpyrexia, anhidrosis

FULL TEXT