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BREAST CANCER BIOMARKERS: A QUICK REVIEW

Dr. Hooria Asif, Dr. Mahmood Asif, Dr. Zainab Tayyab

Carcinoma of breast is a highly prevalent tumor in females and about 1 million cases of this cancer are reported annually worldwide. Brest cancer is responsible for second highest number of deaths globally. In addition to tests like mammography, biopsy, MRI, sonography, ELISA and RIA, measurement of progesterone receptors (PR), estrogen receptors (ER), and human epithelial growth factor receptor 2 (HEGF-2) should also be measured. Because of heterogeneity of breast cancer, new biomarkers have proven to be useful for their predictive significance. Levels of glyco-proteins, microRNA, DNA biomarkers, circulatory tumor cells (CTC) and autoantibodies should always be measured wherever the facilities are available especially in developing countries for timely and proper diagnosis and subsequent management of breast cancer. Key Words:Carcinoma, breast, biomarkers, tumor receptors, CEA, tumor proteins.

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