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PHENOLIC CONTENTS, CYTOTOXICITY AND ANTIMICROBIAL ACTIVITY OF FIVE MEDICINAL PLANTS OF THE LAMIACEAE FAMILY OBTAINED FROM SAUDI ARABIA LOCAL MARKETS

Hasan Yusufoglu *, Ahmed I. Foudah, Mohammed Alqarni, Aftab Alam, Mohammed Ayman Salkini, Elmutasim O. Ahmed

Leaves of Salvia officinalis, Rosmarinus officinalis, Thymus vulgaris, Origanum syriacum, and Lavandula angustifolia were purchased from Riyadh (Saudi Arabia) local market, evaluate physicochemical limits and prepared the methanolic extracts. The total phenolic contents (TPC) of extracts were evaluated using Folin-Ciocalteau reagent, all the extracts showed good quantity of TPC and the decreasing orders were shown as R. officinalis, T. vulgaris, and L. angustifolia, O. syriacum and S. officinalis. Antimicrobial activity was evaluated using the disk diffusion method and all the selected herbs were exhibited some degree of antimicrobial activity. Out of five extracts, three (R. officinalis, T. vulgaris, and L. angustifolia) were found to be the most active agents against B. subtilis, K. pneumonia and C. albicans. The cytotoxicity was evaluated using MCF-7 human breast cancer cell lines, and the extract from R. officinalis was confirmed the most auspicious cytotoxic agents followed by T. vulgaris, and L. angustifolia respectively. Present study, concluded that the extracts of Rosemary, Thyme, and Lavender had a good quantity of phenolic contents, these extracts could be a potent source of antibiotics and effective cytotoxic agents against MCF-7 human cells. Keywords: Lamiaceae herbs, phenolic, antimicrobial, cytotoxic, MCF-7, KSA

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