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MOOD DISORDERS IN STROKE PATIENTS: IMPORTANCE OF LOCALIZATION OF LESION

Dr Badria Munir, Dr Hassaan Imtiaz,Dr Taimoor Jaffar Ali,Dr Abdullah Jamal,Dr Faizan Rasool.

Background: Many studies have shown that post-stroke depression (PSD) results from left hemisphere depression. Two theories has stated on PSD. The first states that depression after brain injury or stroke is a psychological reaction to the consequences of stroke. The second suggests that depression is a consequence of specific brain lesion and presumably subsequent changes in neuro transmitter. Methodology: Out of 184 patients, 48 met the inclusion criteria of this study. Out of those 48 patients only patients who were visualized on CT were included. 22 patients met the criteria and had positive CT with single left hemisphere lesion while 14 met the criteria and had single right hemisphere infarct. Patients were interviewed individually and the purpose of the study was explained prior to informed consent. Results: The severity of lesion was significantly higher in patients with left anterior lesion as compared to any other. Whereas, the severity of depression correlated significantly with proximity of the lesion on CT scan to the frontal pole in the left anterior group. The right hemisphere showed the opposite trend; patients with right posterior lesion were more depressed than patients with right anterior lesion. Conclusion: It shows that intra-hemispheric lesion location is somehow related to mood disorders in stroke patients. Keywords: Cerebrovascular accident, ischemic stroke, depressive disorders disease, mental disorders, mood disorder, neuroanatomy, apathy, right cerebral hemisphere, right handed.

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