ResearcherID - CLICK HERE Scientific Journal Impact Factor (SJIF-2020) - CLICK HERE

SHARE WAVE ELSATROGRAPHY HELPFUL TOOL IN PATIENTS OF CHRONIC LIVER DISEASE CO INFECTED WITH HEPATITIS B&C.

Dr. Mehwish bukhari, Dr. Imran Ali Shaikh, Dr .Naila Masood, Dr. Khalida shaikh.

Objective: The objective of this study was to determine the frequency of degree of liver fibrosis in a patient of chronic liver disease co infected with Hepatitis B and C. Study Design: Descriptive cross-sectional study. Settings: This study was conducted at all medical units of Liaquat university Hospital Jamshoro/Hyderabad. Duration of Study: 01 year July 2016 to July 2017. Methodology: This study included patients (182 patients) recruited from all medicine units of Liaquat university Hospital Jamshoro/Hyderabad. All the patients who fulfilled the inclusion criteria were included in the study. Taking detailed history after obtaining informed consent, demographic data (name, age, sex, duration of CLD etc.) were collected. Surface antigen (HbSAg) and anti-HCV antibody tests was performed by using ELIZA METHOD for diagnosing Hepatitis B and C. Shear wave elastography was performed by consultant and scoring was F0 No fibrosis, F1 Portal fibrosis without septa, F2 Portal fibrosis with few septa, F3 numerous septa without cirrhosis and F4 Cirrhosis. SPSS 16 was used , chai square as applied and p value considered 0.05 significant. Results: In current study, 182 patients were selected out of which 121 (66.5%) patients were male and 61 (33.5 %) were female. Liver fibrosis stages in selected patients were confirmed as; 12 (6.6%) patients of Fl (portal fibrosis without septa: minimal fibrosis), 76 (41.8%) patients of F2 (portal fibrosis with a few septa: moderate fibrosis or clinically significant fibrosis), 64 (35.2%) patients of F3 (septal fibrosis with many septa but no cirrhosis: severe fibrosis) and 30 (16.5%) patients of F4 (cirrhosis). Conclusion: Shear wave elastography of the liver is an effective predictor for determining liver fibrosis stages in patients having chronic liver diseases co- infected with Hepatitis B and C, which will help in early screening, monitoring and management of chronic liver diseases co-infected with Hepatitis B and C. Key Words: Liver fibrosis, cirrhosis, morbidity, mortality, hepatitis C

FULL TEXT