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ASSESSMENT OF CHANGES IN INDICATORS OF OXIDATIVE STRESS, INFLAMMATION AND ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH CORONARY ARTERY DISEASE WITH DIFFERENT SMOKING STATUS

Yulia A. Kotova, Anna A. Zuikova, Alexandr N. Pashkov, Natalia V. Strahova, Olga N. Krasnorutskaya

The aim of the study was to study changes in markers of oxidative stress, inflammation and endothelial dysfunction in patients with coronary artery disease, depending on the status of smoking. Materials and methods: we examined 354 patients with a diagnosis of coronary artery disease, verified by standardized validated criteria and clinical and functional methods, aged from 47 to 75 years. The presence of coronary atherosclerosis was confirmed by coronary angiography followed by the calculation of the Gensini index. According to smoking status, patients were divided into 2 groups: 1 group - non-smokers - 188 people, 2 group - smokers - 166 people. Statistical processing of the research results was carried out using SPSS Statistics 20 software packages. Results: The study shows the characteristics of the severity of coronary atherosclerosis, calculated using the Gensini index, depending on the smoking status. Significant differences in indicators of oxidative stress and homocysteine in patients with different smoking status were revealed. In addition, the relationship between smoking status and biomarkers under study, as well as clinical and anthropometric indicators, was established. Keywords: smoking, oxidative modification of proteins, superoxide dismutase, coronary artery disease, Gensini index, endothelial dysfunction, inflammation.

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