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TO DETERMINE THE SIMVASTATIN EFFECTS ON SENSITIVITY OF INSULIN IN TYPE 2 DIABETIC PATIENTS

Dr Aftab Rabbani, Dr Komal Zia Rao, Dr Mohammad Atiq Ur Rehman

Objective: To investigate the simvastatin treatment effects on sensitivity of insulin in type II diabetic patients. Study Design: A randomized case control study. Place and Duration: In the Medicine Unit II of Jinnah Hospital, Lahore for Six months duration from January 2019 to June 2019. Methodology: In total 100 cases of type 2 diabetes in both sexes were selected for study. Into 2 groups; Patients were divided randomly. 50 subjects were treated with simvastatin 40 mg / day for 3-months and 50 subjects as control. The anthropometric characteristics were same in both groups like (diabetes duration, age, blood pressure and BMI) and biochemical (fasting plasma glucose, serum creatinine, lipid profile and fasting insulin level). By homeostasis model for insulin resistance (HOMA-IR); Insulin resistance was determined earlier and later three months of management with simvastatin (40 mg / day). Results: Simvastatin (40 mg / day) significantly reduced cholesterol, LDL and triglyceride levels, but have no affect significantly on sensitivity of insulin as determined by HOMA-IR. Though, sensitivity of insulin was increased in people with insulin resistance (decreased HOMA IR 1.92; p = 0.001). Conclusion: Although treatment with simvastatin did not affect insulin sensitivity in the short term (3 months), all patients had a significant lipid lowering effect. Key words: Diabetes, insulin sensitivity, lipid profile, simvastatin.

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