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FORMULATION AND EVALUATION OF METOPROLOL SUCCINATE EXTENDED RELEASE TABLETS COMPRISING COATED PELLETS

V. Madhu Sudarsan*, S.T.V. Raghavamma, N. Rama Rao

The objective of the present study was for improving bioavailability and reducing the dosage frequency of Metoprolol succinate in the form of extended release pellets by pan coating technology. Preliminary studies with different polymers such as Surelase, Ethyl cellulose N50, Kollicoat SR 30D were performed. The results of in-vitro release data showed that Kollicoat SR 30D can Extend the drug release up to 24hr. Metoprolol succinate extended release tablets were prepared by MUPS Technique. The hardness of these extended release tablets was within the limit. The drug content was within the range, 98.23±0.25 to 102.03±2.45%. The in-vitro Metoprolol succinate release from the tablets was found Extended over 24 hours with korsmeyer-peppas kinetics of drug release and release pattern followed Super case- II transport. The Fourier transform Infrared spectroscopy (FT-IR) analyses indicated that there was absence of any chemical interaction between the drug and the excipients. The dissolution profiles of the developed formulation and the commercial tablet formulation, Seloken, were compared using the similarity factor (f2)and difference factor (f1). The released profile of tablet containing 7.5%KollicoatSR 30D by weight was similar to that of Seloken® providing the values of similarity factor (f2) 79.4and difference factor (f1) 4.8 of and respectively. The results of Accelerated stability studies showed that all parameters were within the expected specifications and there was no significant changes observed from initial to 3months, indicating good stability. Keywords: Ethyl cellulose N50, Kollicoat SR 30D, Metoprolol succinate, Surelase.

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