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TITLE:

HYPERHOMOCYSTEINEMIA IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD)

AUTHORS:

Dr. Kamlesh Kumar Ahuja, Dr. Jetesh Kumar, Dr. Khadim Hussain, Dr. Shumaila Khalil, Dr. Imran Karim and Muhammad Jan Khetran

ABSTRACT:

Objective: To determine the frequency of hyper homocysteinemia in patients with non- alcoholic fatty liver disease (NAFLD) Patients and Methods:A total of fifty patients Non-alcoholic fatty liver disease were included in the study during six-month study period. The criterion for the selection of the patients for the study was those patients diagnosed case of NAFLD. The exclusive criteria were known patients of chronic viral hepatitis, liver abscess, hepatoma, acute hepatitis, connective tissue disorders, and hematological malignancies, pregnant and lactating ladies. After having selected cases for the study, careful history & physical examination was carried out in each patient in particular relation to abdominal examination. The demographical and clinical profile of subjects was also noted. The co-morbidities were also explored while the serum homocysteine level were also to be explored through laboratory parameters along with routine investigations whereas the frequency / percentages (%) and means ±SD compute d for study variables. Results: During six month study period total fifty patients had NAFLD were explored and study. The mean ± SD for age (yrs) of population was 53.73±6.63. Regarding gender distribution male 20(40%) and female 30 (60%) and hyper homocysteinemia was observed in 32 (64%) patients respectively. Conclusion: Homocysteine was altogether connected with the existence of NAFLD. KeyWords: Hyperhomocysteinemia, non- alcoholic fatty liver disease and homocysteine

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