- CODEN : IAJPBB
- issn 2349-7750
TITLE:
CLINICAL PROFILE AND PREDICTORS OF SEVERE DENGUE DISEASE: A STUDY FROM PAKISTAN
AUTHORS:
Dr Sameen Asim Choudhry, Dr Hafiza Aisha Tahir, Dr Zainab Tahir
ABSTRACT:
Background: Dengue is endemic and prevalent in tropical and sub-tropical countries including Pakistan and can cause significant mortality and morbidity. There are limited studies available on factors associated with severe dengue from Pakistan, to investigate the predictors of severe dengue in patients. Study Design: A cross-sectional study was conducted in Services Hospital Lahore, for the duration of one year, from March 2019 to March 2020. Methods: We recruited 334 patients with dengue admitted in Services Hospital, Lahore. Based on clinical symptoms, we divided patients into severe dengue and non-severe dengue. Univariate and multivariate analysis was performed for prognostic factors of severe dengue. Results: Out of 334 patients, there were 186(55.6%) males with mean age 30.3±14.3 39 years (age range: 10-73 years), severe dengue was seen in 117(35%) and non-severe dengue in 217(65%). Clinical symptoms of diabetes, low platelet count (5days after onset) elevated hematocrit, lymphadenopathy, hepatomegaly, splenomegaly, convulsions and mortality were significantly associated with severe dengue. After multivariate analysis, diabetes (OR: 2.12; 95% CI: 1.34-4.65) (5days) were independently associated with severe dengue. Conclusion: Clinical features and laboratory findings are closely related to confirmed and probable dengue cases. The incidence of dengue fever was much higher during the hot and humid months between August and October. Keywords: Clinical manifestation, Univariate, multivariate, elevated hematocrit, lymphadenopathy.
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