::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

NFKBIA PROMOTER POLYMORPHISMS CONTRIBUTE TO A DECREASED RISK OF OVARIAN CANCER

AUTHORS:

Dr. Muhammad Fasih Tariq, Dr. Hafiza Mahnoor Fatima, Dr. Mariyam Khalid

ABSTRACT:

Introduction: Ovarian cancer is one of the leading forms of cancer, in worldwide. Each year, there is an estimated 225,500 new incidences of ovarian cancer cases globally. The lack of effective screening methods causes >70% of ovarian cancer patients to be diagnosed at late stages, which leads to the low 5-year survival rate and high mortality rate of the disease. Objectives of the study: The basic objective of the study is to find the NFKBIA promoter polymorphisms which contribute towards the decreased risk of ovarian cancer in females. Materials and methods: This cross sectional study was conducted in Bahawal Victoria Hospital, Bahawalpur during June 2019 to March 2020. The genomic DNA obtained was then used in polymerase chain reaction (PCR). Result: The association of the inflammatory gene polymorphisms with ovarian cancer risk was measured in OR units, with the wild type genotype served as the reference. Conclusion: It is concluded that there is no association found in NFKB1A genetic polymorphism and ovarian cancer in local population of Pakistan.