::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

EVALUATION OF EFFECTS OF ORAL CLONIDINE AS PRE-MEDICATIVE DRUG ON THE FUNCTIONS OF KIDNEY

AUTHORS:

Naila Munawar, Nida Siddiquee, Mehak Alam

ABSTRACT:

Objective: The purpose of this research work was to evaluate the impacts of oral clonidine as a pre-medicative drug on 24-hour urine output, specific gravity of urine, renin activity of plasma as well as electrolytes levels of serum & urine. Methodology: This research work was carried out on 50 females from 20 to 40 years of age who were undergoing the cystocoele-rectocoele perineorraphy repair under GA (General Anesthesia) in Benazir Bhutto Hospital Rawalpindi in the year of 2019. We randomly separated the patients into groups with 25 patients in each group. Group-1 and Group-2 took tablets of clonidine at the dose of 5.0 μg/kg and tablet of placebo, respectively, 90 minutes before the application of General Anesthesia. In this research work, we obtained the samples of urine and blood for measuring laboratory parameters before and after six hours of receiving the tablets. The comparison of the differences between the patients of both groups was carried out with the help of Mann-Whitney test, and student T test. We considered the P value of less than 0.050 as significant statistically. Results: We found no important alterations prior and after taking the tablets in the level of blood K and Na as well as the specific gravity of urine in Group-2 (P >0.050). There was high level of urine Na & K in the patients of Group-1 (P=0.0010), however, there were no significant differences in the levels of blood’s K & Na (P>0.050). Specific gravity of urine was much low in the patients of Group-1 after taking the tablets (P<0.0090). An important rise in 24 output of urine (P=0.0010) and a significant reduction in the renin activity of plasma was visible in the patients of Group-1 (P=0.0010). Conclusion: The findings of this research work confirmed that clonidine is a secure pre-medicative medicine in General Anesthesia and it is not the factor behind the alterations in levels of serum electrolytes. KEYWORDS: General Anesthesia, Alterations, Gravity, Renin, Electrolyte, Statistically, Urine, Clonidine.