Taarique Deshmukh*, Dr. Rakesh Kumar Jat, Dr. Rashid Akhtar
Diabetic nephropathy is the medical term for kidney disease caused by diabetes. This is a randomized, open controlled multicenter (observational) clinical trial; conducted on 150(n) patients having type 1 and type 2 diabetic in which (122 men and 28 women) between age 40–80 years who had diabetes for at least 3-4 years, The effect of antioxidant treatment on renal parameters like, microalbuminuria, creatinine, glycemic parameters like HbA1c%, fasting & PP BSL and even though analyses the effect on blood pressure in case of diabetic hypertension was checked. And patients in vitamin group was receiving daily supplement of antioxidant vitamin. The follow up done after 3 months of supplementation, which indicates levels of UAE decreased in, Vitamins group compare to control group (p = 0.0001, p = p<0.0327* respectively) even the effects are observed in HbA1c as well as serum creatinine are around same significant decreased in Vitamins group as compare to the control group; except less significant or non-significant in the cases of rest parameters like blood sugar level, systolic BP & diastolic BP did not significantly change in any group. 210(n) patients observed with the OPD data to get proper guidance of etiological factors responsible for moving the patients towards CKD. The data study demonstrates some possible causes and the conclusion of treatment with vitamins E is that significantly lowers UAER, HbA1C% and serum creatinine but in up to some extent BSL in diabetic nephropathy patients. Key Words: diabetic nephropathy; microalbuminuria; vitamin E; oxidative stress and antioxidants.