::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

FORMULATION AND INVITRO EVALUATION OF CONTROLLED RELEASE TABLETS OF PROPRANOLOL HCL AND MIGLITOL

AUTHORS:

Ramavath Aruna*, Shafiya Fatima, Mohammed Ibrahim, Swetha Reddy, Ayesha Qureshi, Farheen Naaz, Shaik Ejas, Imaduddin.MD

ABSTRACT:

Propranolol hydrochloride is used to treat high blood pressure, thyrotoxicosis, capillary hemangiomas, performance anxiety, and essential tremors and used to prevent migraine headaches and Miglitol acts by inhibiting the ability of the patient to break down complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates. In this investigation-controlled release tablet of Propranolol Hcl and Miglitol were prepared using different polymers such as xanthum gum, tragacanth, sodium carboxymethyl cellulose, HPMC K4M, Eudragit S100, ethyl cellulose by direct compression method. All the pre-compression and post compression parameters of designed formulations of F1- F8 were evaluated and found to be within permissible limit. The optimized formulation (F7) showed maximum percentage of drug release (100%) within in 6hrs when compared to other formulations. From the FT-IR and DSC evaluation study it was concluded that there was no possible drug and polymer interactions. The short-term stability studies were carried out at 40±2˚C and 75±5% RH and were confirmed about no changes in the weight, hardness and friability. Based on study results it may be concluded that tablets prepared will emerge as eminent candidate in treatment of hypertension and diabetes. Key Words: Propranolol Hcl, Miglitol, controlled release tablet, Eudragit S100, sodium cross carmallose, Ethyl cellulose, Tragacanth, HPMC K4M.